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554-556 Mangiferin appears to act as an inhibitor of catechol-O-methyltransferase (COMT), an enzyme responsible for breaking down neurotransmitters such as dopamine, epinephrine, and norepinephrine

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While pathological hypoxia contributes to these inhibitory effects, physiological hypoxia ( 5% O 2 ) is essential for normal NP cell function

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