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Claudins, particularly claudin-5, are crucial for maintaining BBB integrity

10.1021/acs.jmedchem.2c00949 14 GuptaS.WangM

A little EMFs here, a little water toxin exposure there

Furthermore, the elucidation of the viral entry mechanism through mGluR2, due also to its predominant expression in brain tissues, unlike the recognised internalising receptor ACE2, may provide insights into the severe impact of COVID-19 on the brain and its intricate relationship with astrocyte damage, aberrant neuroinflammation, excitotoxicity, impairment of the glymphatic system as well as DLPFC and hippocampal injury [18, 233, 239]

In this review article, the most commonly used form of extraction was alcoholic (ethanolic and methanolic), followed by aqueous, petroleum ether and ethyl acetate