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The above change is associated with long-lasting decreases in the expression of the glial glutamate transporter 1 (GLT-1) and the cystine-glutamate exchange system/antiporter (system x c ) within the nucleus accumbens and/or prefrontal cortex related to downregulation of the genes encoding the latter system [6,7,8,9,10,11]

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3) at the transcriptome level, increasing mRNA expression of Caspase3 and decreasing PPAR , resulting in the apoptosis of adipocytes and inhibition of adipogenesis, respectively, collectively resulting in a reduction in the number of adipocytes (Saeed et al., 2017a)

doi: 10.1038/233058a0

Figure 1 When iodine is sufficient in the body, the production of H2O2 is the step that limits the synthesis of thyroid hormones