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Description
[28] This symmetry of active site results in the different binding mode of the enzyme: It can bind with two dihydrofolate (DHF) molecules with positive cooperativity or two NADPH molecules with negative cooperativity, or one substrate plus one, but only the latter one has the catalytical activity
Numbers increase in childhood
A good nucleophile exhibits a low value of , whereas a good electrophile exhibits a high value of [54]
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