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Recently, Kitamura and colleagues (30) have found that reduction in zinc levels following intracerebroventricular injection of Ca-EDTA prior to focal ischemia accelerated the early development of the infarct, suggesting the need for a minimum complement of zinc to maintain cellular viability, even during cerebral ischemia

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Silymarin, a natural compound from the milk thistle plant, has a protective mechanism that prevents the reception of xenobiotics, including toxic substances found in mushrooms, by hepatocyte surfaces