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Numerous in vitro studies show that ITCs induce apoptosis via both intrinsic and extrinsic pathways (108)for instance, through caspase activation (109), mitochondrial dysfunction (110), and oxidative stress generation (111)
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Some may benefit from twice-weekly dosing depending on: Dosing is individualized after medical evaluation
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
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