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Description
High levels of PHGDH protect GBM cells from hypoxia-induced cell death and starvation by regulating redox homeostasis and the NADPH/NADP+ ratio [29]

Lands LC et al

The biological basis for this is documented in the 2007 Pyo study and the 2018 Pickart review

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When looking at the endogenous NAD + fluxes at the systemic level, most organs do not synthesize NAD + de novo, but can utilize NAM made in the liver 39
