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In addition, other studies indicated that Zn supplementation prevented T2DM-induced liver injury through the activation of the Nrf2-MT-mediated antioxidative pathway [154]

5a and Supplementary Fig

A low carbohydrate diet, even so far as going to a ketogenic diet, may be helpful

The protein biomarkers include cytoplasmic aconitate hydratase (ACO1), argininosuccinate synthase (ASS1), fumarylacetoacetase (FAH), fructose-1,6-bisphosphatase 1 (FBP1) and carbamoylphosphate synthase (CPS1) ( In the past decade, using biomarkers to predict, monitor and diagnose drug-induced diseases during drug treatment or clinical trials has gradually gained wide attention among professionals ( 3.2 Predictive models for screening DILI 32% of post-approval withdrawals and 22% of clinical trial failures are caused by drug hepatotoxicity ( in vitro models for DILI risk prediction

doi: 10.1016/j.abb.2005.10.018 117 ManuelR.MaChadoA.SerralheiroR