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Caution is advised in patients with bronchoconstrictive or bronchospastic lung disease (e.g., asthma)

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Stomach pain and general digestive upset, causing nausea or vomiting

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Treatment of Recurrent Disease After Prior Chemotherapy The efficacy of pemetrexed was evaluated in Study JMEI (NCT00004881), a multicenter, randomized (1:1), open-label study conducted in patients with Stage III or IV NSCLC that had recurred or progressed following one prior chemotherapy regimen for advanced disease

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