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HepG2 cells were transfected with a PPAR response element (PPRE) reporter (PPREx3-TK-luciferase), human PPAR and Renilla constructs and treated with or without NaOX or with the PPAR agonist Wy 14,643 as a positive control 46

Nature 275 , 635637

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All experiments were performed according to the manufacturer's protocols, and the primer sequences used were presented in Table I

A systematic review and meta-analysis of 7,825 individuals and 479 individuals, respectively, performed the impact of up to 12 families of EDCs on male infertility (semen quality, DNA integrity and pregnancy rate or fecundability), the data analysis showed a high heterogeneity among studies