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Description
Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum

doi:10.2174/1381612826666200523180301 National Center for Biotechnology Information
This distinction fundamentally shapes its pharmacokinetic profile, granting it properties (oral bioavailability, protease resistance, BBB penetration) that most neuropeptides lack
The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52

Gently blow your nose to clear any congestion before administration
