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For extended preservation lasting months or years, ultra-low freezing is preferred

Other studies showed that treatment of MKR mice with PPAR- agonists, such as rosiglitazone and pioglitazone, markedly improved lipid metabolic profiles and adipose tissue insulin sensitivity, yet failed to reverse hyperglycemia and hyperinsulinemia, similar to what observed in this study (69)

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However, p53 can protect cells by eliminating ROS under mild stress