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The PDHA1 encoded enzyme is known to function in the nucleus in addition to its role in the PDHc in the mitochondria

Frana et al

However, genetic loss of the rate-limiting enzyme, carnitine palmitoyl-transferase 1A (Cpt1A), a protein found in the outer mitochondrial membrane, did not reduce Treg cell numbers or function in vitro or in vivo (100)

[DOI] [PubMed] [Google Scholar] 167.De Luca A., Rotili D., Carpanese D., Lenoci A., Calderan L., Scimeca M., Mai A., Bonanno E., Rosato A., Geroni C., et al