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1 Introduction Epstein-Barr Virus (EBV) is a ubiquitous oncovirus that affects more than 90% of adults worldwide, but is especially endemic in East Asia, South East Asia, North Africa and Polynesia ( While EBV-associated epithelial cancers vary in presentation and cell origin, these malignancies have in common a viral-mediated immune-suppressed tumor immune microenvironment, mutational signatures and epigenetic hallmarks ( We aim to discuss the pathogenesis of NPC and EBVaGC, and hypothesize the pathogenesis of LELC based on their common epigenetic, genomic and somatic mutational signatures

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doi: 10.1007/s12640-019-00147-2 176 TangYLeW