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The clinical standard of dosage of carboplatin is usually a 4:1 ratio compared to cisplatin

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In contrast, the elevation of ROS level above the cellular tolerability threshold leads to cell death, suggesting that high ROS levels can block cancer progression (118)

Although speculative, it is possible that A 142 aggregation is enhanced in the acidic lysosomes due to the high concentration of copper required for antimicrobial activity via copper induced ROS formation from lysosomal H 2 O 2 (Schtzmann et al., 2021