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Restoration of cellular function by GSTM2 in GSTM1 -null individuals To verify the observed compensatory role of GSTM2 in the absence of GSTM1 , a cell culture-based approach was employed
Through the inhibition of phosphoinositide 3-kinase (PI3K), 3-MA disrupts the formation of autophagosomes, thereby impeding the initiation of the autophagic process

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In addition to a notable elevation of Nrf2, the administration of lutein demonstrated elevated expression levels of downstream genes HO-1 and NQO-1

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