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Enforced asymmetry in repair of each strand break can extend to the gap-filling polymerase employed, and whether the polymerases incorporate RNA or DNA

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In other clinical trials and in real-world use, at initiation of treatment, apomorphine sublingual film is titrated to the maximum efficacious and tolerated dose to provide a clinical benefit for the individual patient, thus overcoming some of the interpatient variability concerns observed in this small, single-dose study [17, 18, 24]

Patient-specific factors such as baseline pain severity and OA phenotype influenced the therapy responses