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As key players in the immune responses of the CNS, both astrocytes and microglia are central to the inception of CNS autoimmunity by regulating autoantigen-presentation, BBB or blood CSF barrier breakdown and aAB leakage, as well as adaptive T- or B-cell activation for aAB production (Ikeshima-Kataoka, 2016

[PubMed] [Google Scholar] Novinscak T., Brcic L., Staresinic M., Jukic I., Radic B., Pevec D., et al

This upregulation is likely a cellular defense mechanism against the elevated reactive oxygen species (ROS) generated during the surgical procedure and early recovery phases 15

The glycerol moiety of the fragment lied adjacent to Leu365, Ser366, Glu410, Glu413, Glu414, and His433, with the side chain of Glu410 capable of forming hydrogen bonds with the hydroxyl groups of glycerol

In summary, while peptide-based wound dressings offer significant promise owing to their targeted biological activity and potential to enhance healing, numerous scientific, technical, and regulatory challenges still remain to be addressed before their full clinical potential can be realized