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Current evidence suggests that stroke destroys the integrity of the IEB and can lead to enterogenic sepsis (Stanley et al., 2016)

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Senthil Kumar K., Valarmathi S., Siddique M.A.M., Kumar T.A., Chiranjeevi K

Therefore, inhibition of hyperactivated mTOR may represent promising therapeutic targets for AD (Cassano and Magini 2019).Similarly, in the pathogenesis of MS, peripheral immune cells penetrate the BBB into the brain and destroy myelin membranes and neurons (Alavi and Fanoudi 2023)

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This action might be used in the treatment of periodontitis and inflammatory bowel diseases such as ulcerative colitis [28, 29, 30]