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Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats

Our results indicate increased DNA damage and reduced DNA repair are key targets of the dual agent treatment, and together these suggest the cancer cells are unable to repair increased DNA damage leading to higher cell death, further supporting the potential use of this dual agent as TNBC therapeutic

In the presence of DCZ, RWS stimulation suppresses L2/3 pyramidal cell potentiation, and even causes depression, even when the CF is not co-activated

This includes High-Performance Liquid Chromatography (HPLC) for purity assessment, Mass Spectrometry (MS) for identity confirmation, Amino Acid Analysis (AAA), and tests for residual solvents, endotoxins, and bioburden

[DOI] [PubMed] [Google Scholar] 123.Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR