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Once inflammation subsides, re-epithelialization begins, typically around 23 days after injury, as fibroblasts infiltrate the wound site, initiating collagen and extracellular matrix (ECM) deposition to create a scaffold for tissue repair

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In fact, preclinical research demonstrates that repeated exposure to several addictive substances evokes a drop in basal concentrations of extracellular glutamate [3,4,5]

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