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Journal of Investigative Dermatology, 1999 PubMed The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures Simon A, Emonard H, Hornebeck W, Maquart FX Life Sciences, 2000 PubMed Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ Simon A, Wegrowski Y, Bontemps Y, Maquart FX Journal of Investigative Dermatology, 2000 PubMed These papers establish GHK-Cu's documented effect on matrix metalloproteinase activity and extracellular matrix components in wound-healing models

This polarization, regulated by inflammatory signals, further contributes to neuroinflammation and exacerbates neuronal damage

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Its differential expression in ectopic versus eutopic endometrium, correlation with disease staging, and interactions with other forms of cell death warrant in-depth investigation