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In a genetic mouse model, the loss of zinc transporter Zip10 leads to reduced zinc levels in macrophages, triggering p53-dependent apoptosis [74]
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This action releases the active glutathione directly into the intracellular space
Induction of ferroptosis can synergize with immune checkpoint inhibitors (ICIs) by reshaping the TME towards a more immunogenic state, overcoming resistance mechanisms (45)
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