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Glutathione works at a cellular level, and visible changes appear over weeksnot days

10.1016/j.psyneuen.2005.02.001 Psychoneuroendocrinology 58 GaleaI

doi: 10.1016/j.dsx.2020.04.020 10 WallsACParkY-JTortoriciMAWallAMcGuireATVeeslerD

(2014) reported three proteins [voltage-dependent anion-selective channel protein 2 (VDAC2), superoxide dismutase [Mn] (SOD2), and fructose-bisphosphate aldolase C (ALDOC)] that were S -glutathionylated in autopsied brain specimens (hippocampus, substantia nigra and cortex) (Zahid et al., 2014)

These mutations disrupt iron homeostasis by phosphorylating Rab8a, leading to the sequestration of Tf within lysosomes and potentially promoting iron accumulation and ferroptosis