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Resveratrol (RSV), a natural plant antitoxin with probiotic activity, was found to attenuate TMAO-induced AS by lowering TMAO levels and increasing hepatic bile acid synthesis by remodeling the gut microbiota ( / mice fed a HFD, the abundances of Firmicutes and Verrucomicrobia were changed and the expression of hepatic FMO3 and serum TMAO levels were markedly reduced (Shi et al., 2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 568.Uwitonze A.M., Razzaque M.S

doi: 10.1038/nature11228

These defects typically manifest as severe metabolic disorders, such as cardiomyopathy, encephalopathy, and hypoglycemia

[(accessed on 27 October 2022)];Int
