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Critically, conditionally essential nutrients, when supplied exogenously, correct a clinically relevant outcome measure (Reference Grimble99,Reference Mischley100) In the context of clinical nutrition, Grimble in 1993 proposed five criteria to define conditionally essential nutrients in humans, whereby their deficiency results in either: failure to maintain growth or nitrogen balance, organ dysfunction, delayed recovery, metabolic or clinical abnormalities (Reference Grimble99)

Mol Cell Biochem 146:3537 Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, Laxminarayan R (2014) Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data

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Acknowledgements We are thankful to Prof