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doi: 10.1016/s1535-6108(03)00085-0 175 KimJHParkSSParkSHKimSJMokYJKimCSet al

Resolvins, protectins, and maresins are biosynthesized from essential omega-3 fatty acid precursors, especially EPA and DHA.

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The compounds mechanism involves preferential accumulation in hyperactive melanocytes associated with hyperpigmentation, where it provides sustained enzyme inhibition that reduces melanin synthesis while preserving normal pigment production in surrounding healthy tissue

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