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Everolimus plus exemestane for hormonereceptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2

Periodic transaminases measurements should be made during prolonged treatment with diclofenac because severe hepatotoxicity may develop without a prodrome of distinguishing symptoms

When intake is frequent, doses accumulate, or detox capacity is impaired, glutathione becomes depletedallowing NAPQI to build up and trigger liver cell injury and death (17)

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The transition from beneficial to harmful effects is governed by the efficiency of cellular antioxidant buffers like the NRF2 pathway and the PRX-Trx relay