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Of note, increased serum FGF23 levels have been reported to be associated with the reduction of serum phosphate or 1,25(OH)2D, which in turn may alter bone homeostasis, although further confirmation is required (85,86)

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But the effect size was, to use some medical jargon: Ginormous! An 82% mortality rate in these elderly patients drops to 20% with combination treatment

Accordingly, treating Col4a1 +/G1344D mice using the chemical chaperone, 4-phenylbutyrate to restore the trafficking of misfolded proteins, restores myogenic tone (449)