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Few studies stratify participants by biological signatures such as mitochondrial phenotypes, redox profiles, or folate receptor alpha autoantibodies, even though data indicate differential responsiveness to targeted interventions in defined endophenotypes (Frye et al., 2024

Potential side effects : Although riboflavin is generally considered safe, high doses may cause digestive issues, increased urination, or skin reactions in some individuals

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These effects can lead to damage to cells and tissues, further burdening the liver and other organs involved in detoxification