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and (iv) orchestrates folding, disaggregation, and degradation machineries (autophagy or proteasome-mediated degradation) to ensure that misfolded proteins are either refolded or removed, if permanently misfolded or superfluous

10.1371/journal.pone.0150095 PLoS One 51 IkedaS

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There was no blinding, there was no control group, and there were no validated questionnaires