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Do they persist

Although initial studies indicate that treatments such as iron chelators and lipid peroxidation inhibitors may have cardioprotective effects, their long-term efficacy and safety profiles have not been comprehensively evaluated in clinical trials, leaving significant room for further investigation (Yang T
TsaoCWAdayAWAlmarzooqZIAndersonCAMAroraPAveryCLet alHeart disease and stroke statistics-2023 update: a report from the American heart association

As cited above, the amino acid cysteine is a rate-limiting factor for GSH synthesis, and a variety of both clinical trials and in-vitro/in-vivo data suggest that supplying cysteine as NAC is an effective strategy for enhancing GSH production and intracellular cysteine.Intravenous NAC has been utilized for some time to treat acetaminophen and non-acetaminophen induced acute liver failure by restoring the concentration of GSH, and has been found to be safe and effective

Furthermore, GSH protects against not only reactive oxygen but also nitrogen and sulfur species (Lushchak, 2012)
