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5.2.2 Limitations due to the disease The pathophysiology of mutations or mechanisms underlying the neuronal pathology of mitochondrial diseases is still unknown in most patients, which makes it difficult to interpret the mitochondrial or neural readout in pharmacological screenings

The mechanisms of the effects of H 2 S on cell functions mainly include regulation of the activity of transcription factors, histone modification, DNA damage repair, DNA methylation, and post-translational modification of proteins through the sulfur hydration of H 2 S ( 2 S plays a vital role in multiple pathological and physiological processes, such as anti-inflammation (Mohammed et al., 2021), anti-apoptosis (Tocmo and Parkin, 2019), blood pressure reduction (Zaorska et al., 2019), and the regulation of cell survival/death, cell proliferation/hypertrophy and cell differentiation (Zhang et al., 2017)

10.1007/s11357-017-9966-x 36 Powell-BraxtonL.HollingsheadP.WarburtonC.DowdM.Pitts-MeekS.DaltonD.et al (1993)

It may be that reducing the production of aqueous humor (i.e., beta-blockers, alpha 2-agonists, inhibitors of carbonic anhydrase), promoting drainage through the trabecular meshwork (parasympathomimetics), and through the uveoscleral route (prostaglandin derivatives)