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With its distributed expression the H 1 R participates in ileum contraction, modulates circadian cycle, systemic vasodilatation, bronchoconstriction (allergy-induced asthma), and mediates pruritus (sensation of itchy skin)
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Vanacker et al., 1998) while a decrease has been reported in leaves attacked by some necrotrophic fungi (Gonnen and Schlsser, 1993
