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Conversely, the enzymatic activity of heparanase functions to promote angiogenesis via the release of molecules such as vascular endothelial growth factor and epidermal growth factor that are associated with the heparan sulfate moieties cleaved by the enzyme

Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress

Antioxidants in down syndrome: from preclinical studies to clinical trials

Hohman S