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Kim TJ, LeBourgeois III HW

6 Quetiapine undergoes extensive CYP3A-mediated first-pass metabolism

Weeks thirteen through sixteen continue the escalation to 1.7 mg

Available data suggest that the inadequate ability to activate thermoregulatory cooling mechanisms, as indexed by a reduced ability to sweat, may play an important role in the body temperature alterations observed in depression 15,31

(1979) Cell culture, methods in enzymology, New York, London, San Franciso, Academic Press, Vol