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Documented effects included reduced body and organ weights, elevated serum markers of hepatic injury, and characteristic histopathological lesionssuch as cholangiopathy, hepatocellular necrosis, sinusoidal congestion, and Ito cell proliferation

[DOI] [PMC free article] [PubMed] [Google Scholar] 210.Ma M., Kong P., Huang Y., Wang J., Liu X., Hu Y., Chen X., Du C., Yang H

For example, the Dana-Farber Cancer Institute (DFCI) ALL Consortium reported a 5-year event-free survival (EFS) rate of 81% and an overall survival (OS) rate of 90% for patients with T-ALL who were treated on two consecutive clinical trials between 2005 and 2015.[2] Another example is the COG AALL0434 (NCT00408005) trial for T-ALL that resulted in a 5-year EFS rate of 83.8% and an OS rate of 89.5%.[3] Treatment options for T-ALL Treatment options for T-ALL include the following: Chemotherapy with or without prophylactic cranial radiation therapy