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Considering that heme oxygenase-1 (HO-1) gene KO and treatment with zinc protoporphyrin IX (a HO-1 inhibitor) reduced Fe + levels and ROS-mediated LPO in PR cells, it has been proposed that HO-1 is a critical modulator of PR ferroptosis induced by atRAL (108)

The microsomal enzymes are retinol dehydrogenases (RDH) of the short-chain dehydrogenase/reductase (SDR) family

coli that catalyze decarboxylation, oxidative deamination using molecular oxygen and NAD-dependent oxidation (Haupka et al., E

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Other ferroptosis-associated genes have also been found to be involved in the initiation of endometrial cancer (Supplementary Table S1)