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(38320504) Hematologic : Neutropenia may result from levamisole contamination of cocaine

Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

[DOI] [PMC free article] [PubMed] [Google Scholar] Mattivi F., Guzzon R., Vrhovsek U., Stefanini M., Velasco R

This pathway is active during brain development and plays a role in neural repair after injury