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The 28-day window reflects the timeline where potency retention remains above 90% under proper storage beyond that, degradation accelerates regardless of appearance

Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine Eur J Pharmacol 1995

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Furthermore, measurement of enzyme activities showed decreases in complexes III [16] and IV [15] and no change in complexes I and II