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(2025, May 16)

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3.2.4 Polyphenol Curcumin is a phytochemical isolated from turmeric that has the ability to enhance the antitumour activity of cisplatin and reduce its side effects (Abadi et al., 2022), can directly scavenge free radicals and also enhance endogenous antioxidant enzyme activity by activating the Nrf2 pathway and inducing HO-1 expression to achieve antioxidant effects, which in turn reduce hearing damage (Fetoni et al., 2014).When curcumin is administered together with cisplatin, it exhibits different mechanisms of action depending on the cellular environment and dose, exerting dual antioxidant and pro-oxidant effects (Arwanda et al., 2023)

And as a reminder, GHK-Cu isn't an FDA-approved dietary supplement or performance enhancer

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