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However, it is noted that the clinical outcome of ACI is still variable (Andriolo et al., 2017), and the reasons have not been fully demonstrated

The sample depletion of the target compound was less than 5%, i.e., the criterion of negligible depletion 28

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Epidemiological evidence in some cases hints that the accepted dosages of vitamin B helps only to avoid their marginal deficiency and further benefits could accrue from higher dosages than those provided by RDA (4-5)

Supplementing iron, particularly if severe deficiency is diagnosed, can help alleviate these symptoms and improve appetite