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Similarly, intranasal delivery of pleiotrophin, an astrocyte-derived mediator that reduces pro-inflammatory signaling in astrocytes and microglia and exerts neuroprotective effects reduced disease severity in late EAE (148)

However, 16S rRNA profiling is cost-efficient but rarely resolves beyond genus level and cannot predict functional genes

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76,77 Decreased MAT activity is attributable to alcohol-induced oxidative stress and reactive aldehydes, which can inactivate the liver-specific MAT

Implement comprehensive metabolic phenotyping for patient stratification: Clinical trials of metabolic inhibitors should incorporate advanced metabolic characterization of tumors using multi-tracer PET imaging, hyperpolarized MRI, tissue metabolomics, and analysis of metabolic enzyme expression