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On other hand, prooxidant therapies, including ionizing radiation and chemotherapeutic agents, are widely used in clinics, based on the rationale that a further oxidative stimulus added to the constitutive oxidative stress in tumor cells should, in fact, cause the collapse of the antioxidant systems, leading to cell death [6]

A follow-up meta-analysis by Lewis and colleagues in the BMJ in 2005 confirmed this pattern the MTHFR genotypes effect on disease risk was greatest where folate intake was lowest and diminished where folate intake was adequate [6]

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[DOI] [PubMed] [Google Scholar] Arbo BD, Andr-Miral C, Nasre-Nasser RG, Schimith LE, Santos MG, Costa-Silva D, Muccillo-Baisch AL, Hort MA

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