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These depleted antiviral T cells (PD-1+/Tim-3+) are functionally ineffective, as they are unable to activate and exert their cytotoxic functions in response to antigenic stimulation [227, 229], thus allowing the infection to become even more chronic
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doi: 10.7150/THNO.33452 132 KarapetsaM.PitsikaM.GoutzourelasN.StagosD.Tousia BeckerA.ZakynthinosE
