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doi: 10.1172/JCI118114

The only medication with a dedicated FDA approval for MASH with moderate-to-advanced fibrosis is resmetirom (Rezdiffra) , a liver-directed thyroid hormone receptor- agonist accelerated-approved in 2024 a completely different mechanism from this amylin/GLP-1 combination

of Naturally Occurring

While only a limited number of cases have been identified since the initial report, 22 this unique entity has recently come to the forefront, since the group of Dianna Milewicz 37 has identified mutations in YY1AP1 at the origin of the disease

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