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doi: 10.1016/S0024-3205(03)00476-4
65 ChenSQuanDHWangXTSandfordSKirmanJRBrittonWJet al
They demonstrated that electrophoresis of purified myofibrils treated with cathepsin L resulted in patterns which were almost identical to patterns of proteins recovered from muscle from spawning fish
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In 1978, building on this discovery, Zamecnik and Stephenson 32 used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment
