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When you are eating 800-1200 calories per day (common at higher tirzepatide doses), every calorie counts

There are also certain drugs and health conditions that can increase the likelihood of developing a B12 deficiency such as: alcohol abuse, antacid use, smoking, celiac disease, other digestive concerns, pregnancy, a strict vegetarian or vegan diet, and even natural aging

This study established the core evidence that drives current research interest and it is important to note that this is primarily a preclinical (mouse) evidence base

It is a water-soluble vitamin, meaning excess will be flushed out in the urine

They include implications in the regulation of longevity, obesity, diabetes, and physical performance