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Upon activation, VDR typically forms a heterodimer with RXR, and this complex binds with high affinity to Vitamin D response elements (VDREs), typically of the DR3 type(a direct repeat of the hexameric core sequence separated by three nucleotides), located in promoters or enhancers of target genes via a zinc fingercontaining DNA-binding motif [116].The VDRRXR complex then utilizes its AF-2 domain to recruit coactivators/corepressors and chromatin remodeling enzymes, orchestrating precise transcriptional programs involved in cell proliferation, differentiation, immune homeostasis, antioxidant defense, and barrier function [117120].Given that the skin is a frontline environmental sensor chronically exposed to UV radiation, pathogens, and oxidative stress, the ability of VDR to bridge environmental cues and gene expression is particularly critical in this context

[DOI] [PubMed] [Google Scholar] Hidese S., Ota M., Wakabayashi C., Noda T., Ozawa H., Okubo T., Kunugi H

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These pathways may work together to lessen tissue damage caused by the immune system and restore euthyroidism