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Gut dysbiosis is a disruption in healthy gut microbial balance, promoting CRC through inflammation, impaired barrier function, and altered nutrient processing and mucosal integrity

They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

Mutation and copy number discordance in primary versus metastatic colorectal cancer (mCRC)

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In another case, taurine supplementation has been shown to confer benefit against oxLDL mediated endothelial dysfunction, as shown by in vitro and in vivo experiments (146)